The Destruction of Santiago occurred when the Spanish conquistadors and the Mapuche-Picunche tribes had a confrontation.

Santiago, Chile’s capital, was destroyed when around 10,000 natives came from the forests to attack the city, which the Spanish colonials had taken. Although the Spanish only lost two men and 15 horses, almost all men were injured. The worst loss was when half the town burned to the ground from a fire caused by the natives.