Anesthetic was used for the first time on a dental patient by Dr. William Morton.
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Mozart's last opera, 'The Magic Flute,' premiered in Vienna.
The NBC broadcasted the first live American football game.
For the first time, scientists captured images of a live giant squid in its natural environment.
The Supremes released their hit single 'Love Child.'
American animated sitcom 'The Flintstones,' which romanticized the Stone Age debuted on ABC.