Due to mosquito infestations, the city of Havana was relocated to its final location.
Spanish navigator Ferdinand Magellan and crew set off aboard the Victoria on their adventure around the globe.
The first battle between the Spanish settlers and the Mexican natives of the Otomi and Tlaxcalans tribespeople started.
Spanish conquistador Pedro Arias Dávila founded Panama City.
Martin Luther had a public debate with theologian Johann Eck at Pleissenburg Castle in Leipzig.
